5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide(CAS: 120210-48-2)

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is a crystalline compound with a molecular weight of approximately 313.04 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound exhibits good stability under acidic conditions and moderate reactivity under basic conditions. It is a white or off-white crystalline solid with a characteristic odor.

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is typically synthesized through a multi-step reaction involving the condensation of 2-thiophenecarbonyl chloride with 1-indoline-2,3-dione, followed by chlorination. The reaction is catalyzed by a Lewis acid such as aluminum chloride. The yield is around 75-85%, and the selectivity is high, making it a reliable synthesis method.

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is used in the pharmaceutical industry for the development of certain drugs. It also finds applications in the polymer industry as a precursor for various polymer matrices. Additionally, it is used in the sensors and semiconductors industries for specific chemical sensing and electronic device applications.

When handling 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area, away from direct sunlight and heat sources. In case of a spill, it should be cleaned up using appropriate methods, and the SDS (Safety Data Sheet) should be consulted for detailed guidance on handling and disposal.