2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone | CAS No. 120013-84-5
2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone
Basic Information
CAS Number
120013-84-5
Molecular Formula
C24H29NO4
Molecular Weight
395.5 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
190-192°C
Synonyms & References
English
- 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-, N-oxide, trans-(+/-)-
- trans-donepezil N-oxide
- SCHEMBL1933861
- UNII-C870X5D93I
- 1-Benzyl-4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidine 1-oxide
- UNII-X070Q7TQO8
- 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-oxido-1-(phenylmethyl)-4-piperidinyl)methyl)-
- 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((trans-1-oxido-1-(phenylmethyl)-4-piperidinyl)methyl)-
- 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-oxido-1-(phenylmethyl)-4-piperidinyl]methyl]-
- rac (cis/trans) Donepezil N-Oxide
- Rac(cis/trans)donepezil N-oxide
- Donepezil-N-Oxide
- 147427-78-9
- Q27275306
- Donepezil N-oxide, cis-
- 147427-77-8
- Q27277022
- AKOS030255768
- C870X5D93I
- AS-79340
- 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((cis-1-oxido-1-(phenylmethyl)-4-piperidinyl)methyl)-
- UNII-E928P2KJ7Y
- cis-donepezil N-oxide
- 2-[(1-benzyl-1-oxidopiperidin-1-ium-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
- Donepezil (metabolite M6 (trans))
- AKOS040755464
- 120013-84-5
- Donepezil (metabolite m6)
- X070Q7TQO8
- Donepezil (metabolite M6 (cis))
- FT-0667769
MDL Number
MFCD09840518
FAQ
What are the physical and chemical properties of 2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone (CAS: 120013-84-5)?
2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone is a white crystalline solid with a molecular weight of approximately 428.38 g/mol. It is slightly soluble in water and exhibits good solubility in common organic solvents like methanol and ethanol. This compound is known for its reactivity, particularly in esterification and amidation reactions due to the presence of methoxy groups and amide functionality. It shows significant hydrophobicity and is stable under normal conditions, but care should be taken when exposed to strong acids or bases.
How is 2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone (CAS: 120013-84-5) typically synthesized?
2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone is typically synthesized via a multi-step process involving alkylation, condensation, and methylation reactions. The key steps include the preparation of the 1-benzyl-1-oxido-4-piperidinyl methyl compound, followed by its reaction with 5,6-dimethoxy-1-indanone in the presence of a suitable catalyst. The final product is obtained with high selectivity and yield, often through techniques like recrystallization and column chromatography.
What industries use 2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone (CAS: 120013-84-5)?
2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone is utilized in various industries, particularly in pharmaceuticals for its potential as a precursor in drug synthesis. It is also used in the polymer industry for developing novel materials due to its functional groups. Additionally, it finds applications in the production of sensors, semiconductors, and as a research compound in academic and industrial settings.
What precautions should be taken when handling 2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone (CAS: 120013-84-5)?
Handling 2-[(1-Benzyl-1-oxido-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone requires appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be carefully cleaned up using appropriate absorbents and then disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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