trans-4-(Aminomethyl)cyclohexanecarboxylic acid

Basic Information

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CAS Number

1197-18-8

Molecular Formula

C8H15NO2

Molecular Weight

157.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Physical State

Powder

Melting Point

>300 °C

Boiling Point

300.2°C at 760 mmHg

Water Solubility

1g/6ml

Flash Point

135.357℃

Refractive Index

1.4186 (estimate)

SMILES

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NC[C@H]1CC[C@@H](CC1)C(=O)O

InChI

InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-

InChIKey

GYDJEQRTZSCIOI-LJGSYFOKSA-N

LogP

0.8361000000000001

Topological Polar Surface Area

63.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

139

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Toxicity

LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)

Synonyms & References

English

tranexamic acid
trans-4-Aminomethylcyclohexane-1-carboxylate
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Amstat
amcha
trans-cyclohexanecarboxylic acid
(1R,4r)-4-(aminomethyl)cyclohexanecarboxylic acid
4-(Aminomethyl)cyclohexanecarboxylic acid (trans-)
4-(Aminomethyl)cyclohexanecarboxylic acid
AMCA,AMCHA,HAKU
Tranesamic acid
AMCA
HAKU
TAMCHA
Cyklokapron
Tranexamsaeure
Trans AMCHA
Tranhexamic acid
Transamin
Amikapron
Anvitoff
Cyclocapron
Ugurol
trans-Amcha
Frenolyse
Rikavarin
Trasamlon
Emorhalt
Tranexan
Carxamin
Mastop

MDL Number

MFCD00001466

Customs Code

2922499990

FAQ

What is trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8)?

Trans-4-(Aminomethyl)cyclohexanecarboxylic acid, also known by its CAS number 1197-18-8, is an organic compound with the formula C10H17NO3. It is a cyclic carboxylic acid featuring an amino group attached to a methyl group in the trans configuration. This compound is known for its stability and is commonly used in pharmaceutical and research settings. It has a melting point of approximately 142–144°C and is soluble in water and organic solvents. Its structure makes it a key intermediate in drug synthesis.

What are the main uses of trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8)?

Trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8) is primarily used in the pharmaceutical industry as a building block for the synthesis of various drugs, including antifibrinolytic agents. It is also employed in research for developing new compounds and in industrial applications for chemical manufacturing. Its unique chemical structure allows it to participate in multiple reaction pathways, making it versatile for medicinal and organic chemistry purposes.

Is trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8) safe?

Trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8) is generally considered safe when handled properly. However, it should be treated with caution as it may cause irritation to the skin, eyes, or respiratory system. Safety data sheets recommend using protective gloves, goggles, and ventilation. It is important to follow established safety protocols to minimize exposure and ensure safe handling in both laboratory and industrial environments.

How should trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8) be stored?

Trans-4-(Aminomethyl)cyclohexanecarboxylic acid (CAS: 1197-18-8) should be stored in a cool, dry, and well-ventilated area, away from direct light. It is typically kept in sealed containers to prevent moisture absorption and contamination. Storage conditions should maintain a temperature below 25°C and humidity levels below 60%. Proper storage ensures the compound's stability and prolongs its shelf life for both research and industrial use.