2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one

Basic Information

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CAS Number

119-52-8

Molecular Formula

C16H16O4

Molecular Weight

272.3 g/mol

Basic Physical Properties

Physical State

Powder

Melting Point

110.0 to 113.0 deg-C

Boiling Point

459.3°C at 760 mmHg

Water Solubility

Soluble in water, ethanol and acetone.

Flash Point

171 ºC

Refractive Index

1.4350 (estimate)

SMILES

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COC1=CC=C(C=C1)C(C(=O)C2=CC=C(C=C2)OC)O

InChI

InChI=1S/C16H16O4/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10,15,17H,1-2H3

InChIKey

LRRQSCPPOIUNGX-UHFFFAOYSA-N

LogP

2.6201000000000008

Topological Polar Surface Area

55.760000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

302

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

LRRQSCPPOIUNGX-UHFFFAOYSA-
AC8989
NSC 7960
NCGC00174251-01
CHEMBL370299
AKOS003239372
1,2-di-(4-methoxyphenyl)-2-oxo-ethanol
W-108509
NSC8504
(alpha-Hydroxy-4-methoxybenzyl)-(4-methoxyphenyl)-ketone
HMS1538J02
Benzoin, 4,4'-dimethoxy-
NSC-8504
DS-16803
Benzoin,4'-dimethoxy-
A855847
F1638-0096
Hydroxy-1,2-bis(4-methoxyphenyl)ethanone
4,4'-Dimethoxybenzoin
(+/-)-p-Anisoin
2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone #
AKOS016038120
DTXSID60883311
SY019730
2-Hydroxy-1,2-bis(4-methoxyphenyl)ethanone
SCHEMBL68736
2-Hydroxy-4'-methoxy-2-(4-methoxyphenyl)acetophenone
1-Oxo-1,2-bis(p-methoxyphenyl)-2-hydroxyethane
AI3-23357
4,4?-DIMETHOXYBENZOIN
KUY567Z2QL

MDL Number

MFCD00008411

Customs Code

2914509090

FAQ

What are the physical and chemical properties of 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8)?

2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) is a crystalline solid with a molecular weight of approximately 328.34 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and dichloromethane. Chemically, it is relatively stable under normal conditions but can react with strong bases to produce methoxy derivatives.

How is 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) typically synthesized?

2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) is commonly synthesized via the condensation of 4-methoxybenzaldehyde with phenylacetic acid. The reaction is catalyzed by a strong acid like hydrochloric acid, and the yield is typically around 70-80%. The product is purified by recrystallization from a suitable solvent.

What industries use 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8)?

2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) is used in the pharmaceutical industry for intermediates in drug synthesis, in the polymer industry for modifying properties of polymers, and in the semiconductor industry for organic semiconductor materials. It also finds applications in sensor technology and as a precursor for dyes.

What precautions should be taken when handling 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8)?

Precautions include using appropriate personal protective equipment (PPE) such as gloves and goggles. It should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions. Storage should be in a cool, dry place away from direct sunlight and flammable materials.