Compound Q&A

How is 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) typically synthesized?

Answer

2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one
2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one (CAS: 119-52-8) is commonly synthesized via the condensation of 4-methoxybenzaldehyde with phenylacetic acid. The reaction is catalyzed by a strong acid like hydrochloric acid, and the yield is typically around 70-80%. The product is purified by recrystallization from a suitable solvent.

About

CAS No 119-52-8
English Name 2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one
Molecular Formula C16H16O4
Molecular Weight 272.3 g/mol
SMILES COC1=CC=C(C=C1)C(C(=O)C2=CC=C(C=C2)OC)O
InChIKey LRRQSCPPOIUNGX-UHFFFAOYSA-N
Last Updated: 2025-10-17 07:35

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