FMOC-GLN-OH | CAS No. 118609-68-0

FMOC-GLN-OH

Basic Information

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CAS Number

118609-68-0

Molecular Formula

C20H20N2O5

Molecular Weight

368.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

220 °C (dec.)

SMILES

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C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CCC(=O)N)C(=O)O

InChI

InChI=1S/C20H20N2O5/c21-18(23)10-9-17(19(24)25)22-20(26)27-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H2,21,23)(H,22,26)(H,24,25)/t17-/m0/s1

InChIKey

IZKGGDFLLNVXNZ-KRWDZBQOSA-N

LogP

2.2437999999999994

Topological Polar Surface Area

118.72000000000001 Å²

Hydrogen Bond Donor/Acceptor

4 / 7

Complexity

545

Synonyms & References

English

N-.alpha.-Fmoc-L-glutamine
HY-W011084
AS-12709
118609-68-0
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine
Fmoc-Gln-OH
(2S)-5-amino-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-5-oxopentanoic acid
AKOS015854495
N-{[(9H-Fluoren-9-yl)methoxy](hydroxy)methylidene}-5-hydroxy-5-iminonorvaline
Fmoc-Gln-OH, >=95.0% (T)
AKOS012614534
EN300-81253
AC-17095
4-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-5-amino-5-oxopentanoic acid
(2S)-5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxopentanoic acid
fmoc-glutamine
H11272
L-Glutamine, N(2)-[(9H-fluoren-9-ylmethoxy)carbonyl]-
(2S)-5-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-pentanoic acid
A804063
J-300126
Fmoc-L-glutamine
Fmoc-L-Gln-OH
N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-GLUTAMINE
CS-W011800
F0308
FMOC-GLN
71989-20-3
NS00062999
N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMINE
N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

MDL Number

MFCD00037137

FAQ

What are the physical and chemical properties of FMOC-GLN-OH (CAS: 118609-68-0)?

FMOC-GLN-OH (CAS: 118609-68-0) is a white to off-white solid with a crystalline form. Its molecular weight is approximately 336.38 g/mol. It is slightly soluble in water and more soluble in common organic solvents like DMSO and acetonitrile. FMOC-GLN-OH is reactive towards nucleophiles and can undergo peptide coupling reactions, making it a useful reagent in solid-phase peptide synthesis.

How is FMOC-GLN-OH (CAS: 118609-68-0) typically synthesized?

FMOC-GLN-OH is typically synthesized by coupling FMOC-Cl with L-glutamine using an appropriate base such as diisopropylethylamine (DIPEA). The reaction is carried out in organic solvents like dichloromethane (DCM). The yield is generally moderate to high, and the reaction can be optimized for selectivity and purity.

What industries use FMOC-GLN-OH (CAS: 118609-68-0)?

FMOC-GLN-OH (CAS: 118609-68-0) is primarily used in the pharmaceutical and biotechnology industries for solid-phase peptide synthesis. It is also relevant in polymer chemistry for certain types of functional materials and in the development of biosensors.

What precautions should be taken when handling FMOC-GLN-OH (CAS: 118609-68-0)?

When handling FMOC-GLN-OH (CAS: 118609-68-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area with a fume hood. Spills should be cleaned up using appropriate absorbent materials and the area should be decontaminated. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.