FMOC-GLN-OH(CAS: 118609-68-0)

FMOC-GLN-OH (CAS: 118609-68-0) is a white to off-white solid with a crystalline form. Its molecular weight is approximately 336.38 g/mol. It is slightly soluble in water and more soluble in common organic solvents like DMSO and acetonitrile. FMOC-GLN-OH is reactive towards nucleophiles and can undergo peptide coupling reactions, making it a useful reagent in solid-phase peptide synthesis.

FMOC-GLN-OH is typically synthesized by coupling FMOC-Cl with L-glutamine using an appropriate base such as diisopropylethylamine (DIPEA). The reaction is carried out in organic solvents like dichloromethane (DCM). The yield is generally moderate to high, and the reaction can be optimized for selectivity and purity.

FMOC-GLN-OH (CAS: 118609-68-0) is primarily used in the pharmaceutical and biotechnology industries for solid-phase peptide synthesis. It is also relevant in polymer chemistry for certain types of functional materials and in the development of biosensors.

When handling FMOC-GLN-OH (CAS: 118609-68-0), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a well-ventilated area with a fume hood. Spills should be cleaned up using appropriate absorbent materials and the area should be decontaminated. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.