(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol | CAS No. 1184916-24-2

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol

Basic Information

CAS Number

1184916-24-2

Molecular Formula

C7H6ClN3O

Molecular Weight

183.6 g/mol

AD

Basic Physical Properties

C1=CC(=NN2C1=NC(=C2)CO)Cl

InChI

InChI=1S/C7H6ClN3O/c8-6-1-2-7-9-5(4-12)3-11(7)10-6/h1-3,12H,4H2

InChIKey

NNACWOFKWGHMIQ-UHFFFAOYSA-N

LogP

0.8749999999999998

Topological Polar Surface Area

50.42 Ų

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

169

Synonyms & References

English

  • 6-Chloroimidazo[1,2-b]pyridazinemethanol
  • 6-chloro-Imidazo[1,2-b]pyridazine-2-methanol
  • 6-Chloro-iMidazo[1,2-b]pyridazineMethanol
  • {6-chloroimidazo[1,2-b]pyridazin-2-yl}methanol
  • CTK8E2282
  • KB-146036
  • RP09051
  • SBB069400
  • 6-Chloroimidazo[1,2-b]pyridazine-2-methanol
  • AKOS006343108
  • A803983
  • W-204979
  • 6-Chloroimidazo[1,2-b]pyridazinemethanol, AldrichCPR
  • DTXSID60655030
  • MFCD12406086
  • SY318843
  • 1184916-24-2
  • (6-chloroimidazo[1,2-b]pyridazin-2-yl)methanol
  • DB-061290
  • G11966
  • J-518616

MDL Number

MFCD12406086

FAQ

What are the physical and chemical properties of (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol (CAS: 1184916-24-2)?

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol is a crystalline solid with a molecular weight of approximately 256.04 g/mol. It has poor solubility in water but is more soluble in organic solvents like methanol and ethanol. Chemically, it is moderately reactive, particularly towards nucleophiles and electrophiles due to the presence of the chlorine atom and the imidazo-pyridazinone ring system. It is stable under normal conditions but should be stored in a cool, dark place to prevent degradation.

How is (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol (CAS: 1184916-24-2) typically synthesized?

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol is usually synthesized via a multistep process starting from 2-aminoimidazo[1,2-b]pyridazine. The key steps involve amidation, chlorination, and methylation reactions. Sodium hypochlorite is commonly used as a chlorinating agent, and the yield is typically around 70-80%. The reaction is performed in a controlled environment to ensure high selectivity and purity.

What industries use (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol (CAS: 1184916-24-2)?

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol finds applications in the pharmaceutical industry, particularly in the development of new drug candidates for anti-inflammatory and anticancer therapies. It is also used in the field of organic electronics for the synthesis of novel semiconducting materials and in the production of advanced sensors for detecting environmental pollutants and other analytes.

What precautions should be taken when handling (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol (CAS: 1184916-24-2)?

When handling (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol, ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up with care, using appropriate absorbent materials. Follow safety data sheet (SDS) guidelines for waste disposal, and ensure proper storage in a secure, labeled container away from incompatible materials. Avoid contact with skin and eyes, and seek medical attention if exposure occurs.

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