(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol(CAS: 1184916-24-2)

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol is a crystalline solid with a molecular weight of approximately 256.04 g/mol. It has poor solubility in water but is more soluble in organic solvents like methanol and ethanol. Chemically, it is moderately reactive, particularly towards nucleophiles and electrophiles due to the presence of the chlorine atom and the imidazo-pyridazinone ring system. It is stable under normal conditions but should be stored in a cool, dark place to prevent degradation.

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol is usually synthesized via a multistep process starting from 2-aminoimidazo[1,2-b]pyridazine. The key steps involve amidation, chlorination, and methylation reactions. Sodium hypochlorite is commonly used as a chlorinating agent, and the yield is typically around 70-80%. The reaction is performed in a controlled environment to ensure high selectivity and purity.

(6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol finds applications in the pharmaceutical industry, particularly in the development of new drug candidates for anti-inflammatory and anticancer therapies. It is also used in the field of organic electronics for the synthesis of novel semiconducting materials and in the production of advanced sensors for detecting environmental pollutants and other analytes.

When handling (6-Chloroimidazo[1,2-b]pyridazin-2-yl)methanol, ensure the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up with care, using appropriate absorbent materials. Follow safety data sheet (SDS) guidelines for waste disposal, and ensure proper storage in a secure, labeled container away from incompatible materials. Avoid contact with skin and eyes, and seek medical attention if exposure occurs.