6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one

Basic Information

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CAS Number

118289-55-7

Molecular Formula

C10H9Cl2NO

Molecular Weight

230.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

223.0 to 227.0 deg-C

Boiling Point

393.8°C at 760 mmHg

SMILES

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C1C2=CC(=C(C=C2NC1=O)Cl)CCCl

InChI

InChI=1S/C10H9Cl2NO/c11-2-1-6-3-7-4-10(14)13-9(7)5-8(6)12/h3,5H,1-2,4H2,(H,13,14)

InChIKey

ZTQQXEPZEYIVDK-UHFFFAOYSA-N

LogP

2.615900000000001

Topological Polar Surface Area

29.1 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

234

Safety Information

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GHS Hazard Pictograms

H410

Hazard Statement

H410 Very toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

BCP11915
J-509563
5-(2-Chloroethyl)-6-chlorooxindole
6-Chloro-5-(2-chloroethyl)oxindole
5-(2-chloroethyl)-6-chloro-oxindole
5-(2-chloroethyl)-6-chloro oxindole
UNII-ZT4R5S724X
MFCD03411598
NS00021543
F14939
6-chloro-5-(2-chloro-ethyl)-1,3-dihydro-indol-2-one
5-Chloroethyl-6-chloro-1,3-dihydro-1H-indol-2-one
ZTQQXEPZEYIVDK-UHFFFAOYSA-N
6-Chloro-5-(2-Chloroethyl)-1,3
ZT4R5S724X
5-(2-chloroethyl)-6-chloro-1,3-dihydro-2h-indol-2-one
6-Chloro-5-(2-chloroethyl)-2-indolinone
5-(2-CHLORO ETHYL)-6-CHLOROOXINDOLE
2H-INDOL-2-ONE, 6-CHLORO-5-(2-CHLOROETHYL)-1,3-DIHYDRO-
A22730
SCHEMBL623364
Ziprasidone Impurity F (5-(2-Chloroethyl)-6-chlorooxindole)
AKOS015889238
FT-0642887
C2651
118289-55-7
6-CHLORO-5-(2-CHLOROETHYL)-2-OXOINDOLINE
5-Chloroethyl-6-Chloro-1,3-dihydro-indol-2-one
6-chloro-5-(2-chloro-ethyl)- 1,3-dihydro-indol-2-one
AC-5337
ZB1472

MDL Number

MFCD03411598

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7)?

6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7) is a crystalline solid with a molecular weight of approximately 295.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7) typically synthesized?

6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7) is typically synthesized via the condensation of 2-chloroethylamine with indole-3-carbaldehyde. This reaction can be catalyzed by Lewis acids like aluminum chloride, with good yield and high selectivity. The product is purified by recrystallization from organic solvents.

What industries use 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7)?

6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7) finds applications in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It may also be used in the polymer industry for the development of new materials and in the sensor industry for its ability to interact with specific chemical species.

What precautions should be taken when handling 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7)?

When handling 6-Chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one (CAS: 118289-55-7), it is crucial to wear appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place with good ventilation. In case of spill, it should be contained and disposed of according to safety data sheet (SDS) guidelines. Always work in a fume hood to avoid inhalation risk.