N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1) | CAS No. 116817-11-9
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)
Basic Information
CAS Number
116817-11-9
Molecular Formula
C18H20ClNOS
Molecular Weight
311.45 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
137-139°C
Boiling Point
466.2°C at 760 mmHg
Safety Information
View Safety InformationHazard Statement
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine hydrochloride
- R-DULOXETINE HYDROCHLORIDE
- AKOS015961640
- 116817-11-9
- N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine hydrochloride
- N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride
- ( inverted exclamation markA)-Duloxetine (hydrochloride)
- AS-15954
- HY-B0161E
- A803677
- N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine;hydrochloride
- N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine hydrochloride
- AC-8272
- rac-Duloxetine Hydrochloride (1:1 R:S Mixtures)
- AB23771
- F0001-2382
- N-Methyl-3-[(naphthalen-1-yl)oxy]-3-(thiophen-2-yl)propan-1-amine--hydrogen chloride (1/1)
- FT-0655005
- MFCD06407958
- (S)-N-Methyl-3-[(1-naphthyl)oxy]-3-(2-thienyl)-1-propanamine Hydrochloride
- A807077
- N-methyl-3-(1-naphthalenyloxy)-3-thiophen-2-yl-1-propanamine hydrochloride
- SY030752
- BCP21597
- 947316-47-4
- N-methyl-gAmma-(1-naphthalenyloxy)-2-thiophenepropanamine, hydrochloride
- (+)-(S)-n-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine, hydrochloride/duloxetinehcl
- FT-0667811
- CHEBI:36808
- FT-0648818
- Duloxetine EP impurity A
MDL Number
MFCD09750960
Customs Code
2934999090
FAQ
What are the physical and chemical properties of N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (CAS: 116817-11-9)?
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride is a crystalline compound with a molecular weight of approximately 391.34 g/mol. It has a high solubility in water and moderate solubility in organic solvents. The compound is reactive towards nucleophiles and can undergo substitution reactions. It also displays basic properties due to the presence of the amino group and the hydrochloride salt form.
How is N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (CAS: 116811-9) typically synthesized?
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride is typically synthesized via a multi-step process involving the coupling of naphthol and thiophene derivatives, followed by alkylation and amidation reactions. The synthesis involves the use of reagents like sodium hydride and acetic acid. The overall yield is moderate, around 50-60%, and the reaction is carried out under basic conditions.
What industries use N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (CAS: 116817-11-9)?
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride is used in pharmaceuticals for its potential as an intermediate in the synthesis of various drugs. It may also have applications in the development of sensors and semiconductors due to its electronic properties. Additionally, it might be used in polymer chemistry for specific functionalization purposes.
What precautions should be taken when handling N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (CAS: 116817-11-9)?
When handling N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, it should be handled under a fume hood, and the Safety Data Sheet (SDS) should be consulted for specific spill cleanup procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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