Compound Q&A
How is N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (CAS: 116811-9) typically synthesized?
Answer
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride is typically synthesized via a multi-step process involving the coupling of naphthol and thiophene derivatives, followed by alkylation and amidation reactions. The synthesis involves the use of reagents like sodium hydride and acetic acid. The overall yield is moderate, around 50-60%, and the reaction is carried out under basic conditions.
About
CAS No
116817-11-9
English Name
N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine hydrochloride (1:1)
Molecular Formula
C18H20ClNOS
Molecular Weight
311.45 g/mol
SMILES
CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChIKey
BFFSMCNJSOPUAY-UHFFFAOYSA-N
Last Updated: 2025-10-23 07:31
