Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate | CAS No. 1168152-07-5
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate
Basic Information
CAS Number
1168152-07-5
Molecular Formula
C20H17NO5
Molecular Weight
351.36 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 1H-Indole-6-carboxylic acid, 1-acetyl-2,3-dihydro-3-(methoxyphenylmethylene)-2-oxo-, methyl ester, (3E)-
- methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylidene]-2-oxoindole-6-carboxylate
- (E)-methyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
- (E)-methyl-1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate
MDL Number
MFCD18207134
FAQ
What are the physical and chemical properties of Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5)?
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) is a white or off-white crystalline solid. Its molecular weight is approximately 384.44 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is known for its excellent stability under acidic and basic conditions, with good reactivity in esterification and amidation reactions.
How is Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) typically synthesized?
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) is typically synthesized through a multi-step process involving acylation, alkyl halide addition, and condensation reactions. Common catalysts include titanium(IV) isopropoxide (TIP) and sodium hydride (NaH). The overall yield is around 70-80%, with high selectivity towards the E-isomer.
What industries use Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5)?
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) is primarily used in the pharmaceutical industry for the synthesis of complex organic molecules. It is also applied in the polymer industry for the modification of polymer properties, and in chemical sensors for detecting specific compounds. Additionally, it has potential applications in the semiconductor industry due to its unique chemical structure.
What precautions should be taken when handling Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5)?
When handling Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5), appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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