Compound Q&A
How is Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) typically synthesized?
Answer
![Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate](https://static.chemtradehub.com/structs/116/1168152-07-5-76ae.webp "Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate")
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate (CAS: 1168152-07-5) is typically synthesized through a multi-step process involving acylation, alkyl halide addition, and condensation reactions. Common catalysts include titanium(IV) isopropoxide (TIP) and sodium hydride (NaH). The overall yield is around 70-80%, with high selectivity towards the E-isomer.
About
CAS No
1168152-07-5
English Name
Methyl (3E)-1-acetyl-3-[methoxy(phenyl)methylene]-2-oxo-6-indolinecarboxylate
Molecular Formula
C20H17NO5
Molecular Weight
351.36 g/mol
SMILES
CC(=O)N1c2cc(ccc2/C(=C(/c3ccccc3)\OC)/C1=O)C(=O)OC
InChIKey
IAELOHNWFVWCNO-ISLYRVAYSA-N
Last Updated: 2025-10-28 15:15
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