Cabozantinib s-malate

Basic Information

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CAS Number

1140909-48-3

Molecular Formula

C32H30FN3O10

Molecular Weight

635.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O

InChI

InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

InChIKey

HFCFMRYTXDINDK-WNQIDUERSA-N

LogP

4.447400000000003

Topological Polar Surface Area

193.60999999999999 Å²

Hydrogen Bond Donor/Acceptor

5 / 13

Complexity

924

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
Cabozantinib
Cabozantinib malate (XL184)
(2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide,(2S)-2-hydroxybutanedioic acid
Cabozantinib L-Malate Salt
Cabozantinib S-malate
XL-184 L(-)-Malic acid salt
Cabozantinib malate
Cabozantinib malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide (4-fluoro-phenyl)amide (L)-malate salt
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide L-malate
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-d
Smalate
UNII-DR7ST46X58
XL184
XL-184
N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
(S)-2-hydroxysuccinic acid (1:1)
Cabozantinib s-malate [USAN]
CCG-270301
XL184 (S-malate);BMS-907351 (S-malate)
s4001
N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-2-hydroxysuccinate
cabozantinib L-malate
DR7ST46X58
1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid
Cabozantinib malate (JAN)
1140909-48-3
AC-27471
BMS907351

MDL Number

MFCD20923480

FAQ

What is Cabozantinib s-malate (CAS: 1140909-48-3)?

Cabozantinib s-malate is a prodrug of cabozantinib, which is a multikinase inhibitor used in the treatment of various cancers. It is composed of cabozantinib and s-malate, a derivative of malic acid, which enhances the drug's stability and bioavailability.

What are the main uses of Cabozantinib s-malate (CAS: 1140909-48-3)?

Cabozantinib s-malate is primarily used in the treatment of medullary thyroid cancer (MTC) and renal cell carcinoma (RCC) after failure of prior therapy. It targets multiple kinases involved in tumor growth and progression, making it effective in cancer therapy.

Is Cabozantinib s-malate (CAS: 1140909-48-3) safe?

Cabozantinib s-malate is generally safe when used as directed. However, it can cause side effects such as hypertension, hand-foot syndrome, and fatigue. Patients should consult a healthcare provider for proper dosage and monitoring to minimize risks. Storage and handling should follow safety guidelines to prevent exposure and inhalation.

How should Cabozantinib s-malate (CAS: 1140909-48-3) be stored?

Cabozantinib s-malate should be stored at room temperature (15-30°C) away from direct sunlight and moisture. It should be kept in a tightly closed container to protect against light and air. Avoid storing in high humidity areas to maintain stability and efficacy. Proper disposal should be followed to prevent environmental contamination.