2,6-Dichloroimidazo[1,2-b]pyridazine

Basic Information

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CAS Number

112581-77-8

Molecular Formula

C6H3Cl2N3

Molecular Weight

188.02 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC(=NN2C1=NC(=C2)Cl)Cl

InChI

InChI=1S/C6H3Cl2N3/c7-4-1-2-6-9-5(8)3-11(6)10-4/h1-3H

InChIKey

MGNCSIAIZSTMHX-UHFFFAOYSA-N

LogP

2.0361000000000002

Topological Polar Surface Area

30.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

155

Synonyms & References

English

AKOS006309964
MGNCSIAIZSTMHX-UHFFFAOYSA-N
2,6-Dichloroimidazo[1,2-b]pyridazine
J-507440
A894567
AMY19102
MFCD11044765
DTXSID90560103
AS-38953
112581-77-8
Imidazo[1,2-b]pyridazine, 2,6-dichloro-
SCHEMBL756100
CS-0140540
2,6-dichloro-imidazol[1,2-b]pyridazine
Imidazo[1,2-b]pyridazine,2,6-dichloro
IMidazo[1,2-b]pyridazine,2,6-dichloro-
2,6-dichloroimidazo[1,2-b]pyridazine

MDL Number

MFCD11044765

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2,6-Dichloroimidazo[1,2-b]pyridazine (CAS: 112581-77-8)?

2,6-Dichloroimidazo[1,2-b]pyridazine is a crystalline compound with a molecular weight of approximately 215.03 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. This compound is relatively stable under normal conditions but can undergo substitution reactions with nucleophiles. It is often used in pharmaceutical and industrial applications due to its chemical reactivity.

How is 2,6-Dichloroimidazo[1,2-b]pyridazine (CAS: 112581-77-8) typically synthesized?

2,6-Dichloroimidazo[1,2-b]pyridazine is usually synthesized via a multi-step process starting from chloropyridine and imidazole. The synthesis involves condensation reactions followed by chlorination steps. Commonly used catalysts include hydrogen chloride and thionyl chloride. The overall yield is around 70-80%, with good selectivity towards the desired product.

What industries use 2,6-Dichloroimidazo[1,2-b]pyridazine (CAS: 112581-77-8)?

2,6-Dichloroimidazo[1,2-b]pyridazine is primarily used in the pharmaceutical industry as an intermediate for drug synthesis. It also finds applications in the polymer industry for the development of functional polymers, and in the semiconductor industry for the fabrication of sensors and electronic devices. Additionally, it is used in research for its unique chemical properties.

What precautions should be taken when handling 2,6-Dichloroimidazo[1,2-b]pyridazine (CAS: 112581-77-8)?

When handling 2,6-Dichloroimidazo[1,2-b]pyridazine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure that all work is conducted in a well-ventilated area or a fume hood. Spills should be immediately cleaned up with appropriate absorbents, and the area should be thoroughly washed. Refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions. Due to its chemical nature, it should be stored in a cool, dry place away from direct sunlight and flammable materials.