4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol

Basic Information

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CAS Number

112559-81-6

Molecular Formula

C16H17N3O3

Molecular Weight

299.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

540.8°C at 760 mmHg

SMILES

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C1CN(CCN1C2=CC=C(C=C2)[N+](=O)[O-])C3=CC=C(C=C3)O

InChI

InChI=1S/C16H17N3O3/c20-16-7-5-14(6-8-16)18-11-9-17(10-12-18)13-1-3-15(4-2-13)19(21)22/h1-8,20H,9-12H2

InChIKey

BNHYDULILNJFFY-UHFFFAOYSA-N

LogP

3.28020

Complexity

363

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

SCHEMBL3891177
J-002792
N-(4-hydroxyphenyl)-N'-(4-nitrophenyl)-piperazine
5KE8XH28SR
A802601
CS-0130720
112559-81-6
BNHYDULILNJFFY-UHFFFAOYSA-N
Phenol, 4-[4-(4-nitrophenyl)-1-piperazinyl]-
4-[4-(4-nitrophenyl)piperazin-1-yl]phenol
AKOS008568216
AC-24285
1-(4-hydroxyphenyl)-4-(4-nitrophenyl)piperazine
DTXSID40464167
DS-13491
N-(4-Hydroxyphenyl)-N'-(4'-nitrophenyl)-piperazine
4-(4-(4-Nitrophenyl)piperazin-1-yl)phenol
4-[4-(4-nitrophenyl)-1-piperazinyl]phenol
BCP18700
4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol
4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenol;4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol
MFCD08460988
1-(4-Hydroxyphenyl)-4-(4-nitrophenyl)-piperazine
4-[4-(4-Nitrophenyl)-1-piperazinyl]phenol
4-(4-[4-nitrophenyl]piperazin-1-yl)phenol
N-(4-hydroxyphenyl)-N'-(4'-nitrophenyl)-piperazine
Phenol,4-[4-(4-nitrophenyl)-1-piperazinyl]
4-(4-(4-nitrophenyl)piperazin-1-yl)phenol
4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenol
4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol Itraconazole interMediate
Phenol,4-[4-(4-nitrophenyl)-1-piperazinyl]-

MDL Number

MFCD08460988

Customs Code

2933599090

FAQ

What regulatory guidelines apply to 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6)?

4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) falls under the classification of a hazardous chemical due to its nitro group. It is regulated under the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), which includes health, environmental, and physical hazards. In the European Union, it is subject to the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation, requiring manufacturers and importers to register the substance if quantities exceed thresholds. Additionally, the U.S. Food and Drug Administration (FDA) and Environmental Protection Agency (EPA) have specific guidelines for the use, handling, and disposal of this compound.

Are there alternatives to 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) in synthesis?

Alternatives to 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) in synthesis include other piperazine derivatives such as 4-(4-aminophenyl)piperazine and 4-(1-piperazinyl)benzoic acid. These compounds can serve similar functional roles but may offer better stability, reactivity, or toxicity profiles. Researchers often explore these alternatives to avoid the potential health and environmental risks associated with the nitro group.

What is the market or research trend for 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6)?

The market for 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) is limited due to its restricted use and regulated status. However, ongoing research focuses on its applications in pharmaceuticals, particularly as a precursor for drug synthesis. Recent trends indicate a shift towards safer, more environmentally friendly alternatives. The compound's research interest is mainly driven by its structural complexity and potential biological activity, but it faces challenges due to its toxicity and regulatory restrictions.

How should waste containing 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) be handled?

Waste containing 4-(4-(4-Nitrophenyl)-1-piperazinyl)phenol (CAS: 112559-81-6) should be managed carefully to prevent environmental contamination and ensure worker safety. Collection should be done in sealed, labeled containers. For small quantities, incineration under controlled conditions is a viable option, but professional waste disposal services are recommended for larger amounts. Disposal should comply with local, national, and international regulations. Proper protective equipment and training are essential for handling this compound to minimize exposure risks.