1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole

Basic Information

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CAS Number

110963-63-8

Molecular Formula

C16H23N3O

Molecular Weight

273.38 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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CCOCCN1C2=CC=CC=C2N=C1C3CCNCC3

InChI

InChI=1S/C16H23N3O/c1-2-20-12-11-19-15-6-4-3-5-14(15)18-16(19)13-7-9-17-10-8-13/h3-6,13,17H,2,7-12H2,1H3

InChIKey

YBJXRWANRTYCJE-UHFFFAOYSA-N

LogP

2.5398000000000005

Topological Polar Surface Area

39.08 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

293

Synonyms & References

English

1-(2-Ethoxy-ethyl)-2-piperidin-4-yl-1H-benzimidazole
1-(2-ETHOXYETHYL)-2-(4-PIPERIDINYL)-1H-BENZIMIDAZOLE
1-(2-Ethoxyethyl)-2-(4-piperidinyl)-1H-benziMidazole HCl
1-(2-ethoxyethyl)-2-piperidin-4-ylbenzimidazole
1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-1,3-benzodiazole
1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[D]imidazole
Bilastine intermediate
Bilasten intermediate 2
Bilastine Intermediate 1
1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole
DB-060051
AKOS027383994
BCP08770
1-(2-ETHOXY-ETHYL)-2-PIPERIDIN-4-YL-1H-BENZIMIDAZOLE
1-(2-ETHOXYETHYL)-2-(PIPERIDIN-4-YL)-1,3-BENZODIAZOLE
AC-29251
YBJXRWANRTYCJE-UHFFFAOYSA-N
1-(2-ethoxyethyl)-2-piperidin-4-yl-1H-benzoimidazole
1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole oxalate
1-(2-ethoxyethyl)-2-piperidin-4-yl-1h-benzimidazole
110963-63-8
1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-1,3-benzodiazole;1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]iMidazole
SCHEMBL991263
AMY23147

MDL Number

MFCD18800830

FAQ

What are the physical and chemical properties of 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (CAS: 110963-63-8)?

1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole is a crystalline solid with a molecular weight of approximately 336.41 g/mol. It has limited solubility in water and good solubility in organic solvents like ethanol and dichloromethane. This compound is moderately reactive towards acids and bases. It decomposes above 150°C.

How is 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (CAS: 110963-63-8) typically synthesized?

1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole can be synthesized via a multi-step process involving the reaction of 2-ethoxyethyl bromide with piperidin-4-ylamine followed by coupling with benzimidazole. Commonly used catalysts include triphenylphosphine and dicyclohexylcarbodiimide. The overall yield is around 50%.

What industries use 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (CAS: 110963-63-8)?

This compound finds applications in the pharmaceutical industry as an intermediate for drug synthesis. It is also used in the development of sensors and as a precursor in the synthesis of certain semiconductors. Its use in polymer chemistry is limited due to its specific reactivity profiles.

What precautions should be taken when handling 1-(2-ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole (CAS: 110963-63-8)?

When handling 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Use a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. Refer to the safety data sheet (SDS) for detailed safety information.