5-Methoxy-1H-indole-3-carbaldehyde

Basic Information

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CAS Number

10601-19-1

Molecular Formula

C10H9NO2

Molecular Weight

175.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

178.0 to 182.0 deg-C

Boiling Point

306.47°C (rough estimate)

Flash Point

180.7 °C 1.273 g/cm3

Refractive Index

1.5060 (estimate)

SMILES

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COC1=CC2=C(C=C1)NC=C2C=O

InChI

InChI=1S/C10H9NO2/c1-13-8-2-3-10-9(4-8)7(6-12)5-11-10/h2-6,11H,1H3

InChIKey

TUWARWGEOHQXCO-UHFFFAOYSA-N

LogP

1.9889999999999999

Topological Polar Surface Area

42.09 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

195

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Class AIR SENSITIVE Class AIR SENSITIVE

Sensitiveness

Air Sensitive

Synonyms & References

English

CHEBI:177034
M1268
5-Methoxy-1H-indole-3-carbaldehyde #
5-Methoxyindole-3-aldehyde
NS00023402
FT-0620572
5-Methoxyindole-3-carboxaldehyde, >=99%
MLS000575461
Tert-butyl3-(4-aminophenyl)piperidine-1-carboxylate
10601-19-1
AM20061194
5-methoxy-3-formylindole
5-methoxy-indole-3-carbaldehyde
Q27263605
SMR000184711
VU0208691-3
3-Formyl-5-methoxyindole
1H-Indole-3-carboxaldehyde, 5-methoxy
Oprea1_121493
AC-8769
AKOS000265020
EN300-62417
F3385-4658
NSC 521754
SY001986
5-METHOXYINDOLE-3-CARBOXYALDEHYDE
AB00519716-07
5-Methoxyindole-3-carboxaldehyde
5-Methoxy-3-indolealdehyde
BCP26978
NSC-521754

MDL Number

MFCD00005623

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1)?

5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1) is a white or pale yellow crystalline solid with a molecular weight of approximately 168.17 g/mol. It has a low water solubility but is soluble in organic solvents like ethanol and acetone. This compound is moderately reactive, particularly towards nucleophiles. It is also susceptible to oxidative degradation.

How is 5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1) typically synthesized?

5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1) can be synthesized through the reduction of 5-methoxy-1H-indole-3-carboxaldehyde or by reacting 5-methoxyindole with phthalic anhydride. The reaction involves the use of reducing agents such as sodium borohydride and requires careful control of temperature and pH to achieve high selectivity and yield.

What industries use 5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1)?

5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1) finds application in the pharmaceutical industry for the synthesis of certain drugs, and in the chemical industry for the development of dyes and pigments. It is also used in sensor technology and as a precursor in the semiconductor industry.

What precautions should be taken when handling 5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1)?

Proper handling of 5-Methoxy-1H-indole-3-carbaldehyde (CAS: 10601-19-1) requires wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to avoid inhalation of vapors. Spills should be cleaned up with caution using appropriate materials, and the substance should be stored in a secure, cool, and dry location away from direct sunlight and heat sources.