N,O-Bis(trimethylsilyl) Acetamide

Basic Information

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CAS Number

10416-59-8

Molecular Formula

C8H21NOSi2

Molecular Weight

203.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Melting Point

24 ºC

Boiling Point

71-73 °C/35 mmHg

Solubility

Miscible with many nonpolar and polar aprotic solvents.

Refractive Index

n20/D 1.417(lit.)

Vapor Pressure

2.9±0.3 mmHg at 25°C

SMILES

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CC(=N[Si](C)(C)C)O[Si](C)(C)C

InChI

InChI=1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

InChIKey

SIOVKLKJSOKLIF-CMDGGOBGSA-N

LogP

3.0912000000000015

Topological Polar Surface Area

21.59 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

177

Safety Information

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GHS Hazard Pictograms

H226

H302

H314

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H302 Harmful if swallowed
Acute toxicity, oral

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

N,O-bis-(TRIMETHYLSILYL)-ACETAMIDE
Q2904581
10416-59-8
BSA
C8H21NOSi2
D72517
N,O-Bis(trimethylsilyl)acetamide (TMS-BA)
N,O-Bis(trimethylsilyl)acetamide
DTXSID5051525
FT-0663405
B0511
Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
Trimethylsilyl N-(trimethylsilyl)ethanimidoate
trimethylsilyl N-trimethylsilylacetimidate
TRIMETHYLSILYL N-(TRIMETHYLSILYL)ETHANIMIDATE
N,O-Bis(trimethylsilyl)acetamide, 95%
trimethylsilyl N-trimethylsilylethanimidate
n,o-bis (trimethylsilyl)acetamide
NS00052260
BCP24460
N-trimethylsilyl-acetylimidic acid trimethylsilyl ester
n,o-bis(trimethylsilyl) acetamide
N,O-bis(trimethlsilyl)acetamide
TMS-BA
(E)-trimethylsilyl N-trimethylsilylacetimidate
N,O-Bis(trimethylsilyl)acetamide pound>>Bis(trimethylsilyl)acetamide (BSA)
AKOS028108367
trimethylsilyl (E)-N-(trimethylsilyl)acetimidate
B0510
(E)-trimethylsilyl N-(trimethylsilyl)acetimidate
(E)-trimethylsilyl-N-(trimethylsilyl)acetimidate

MDL Number

MFCD00008270

Customs Code

29310095

FAQ

What is N,O-Bis(trimethylsilyl) Acetamide (CAS: 10416-59-8)?

N,O-Bis(trimethylsilyl) Acetamide is a silylating agent with the chemical formula C6H16N2OSi2. It is a white solid that is commonly used in organic synthesis due to its ability to protect amino groups. The compound is known for its stability and low reactivity under normal conditions, making it a valuable tool in chemical research.

What are the main uses of N,O-Bis(trimethylsilyl) Acetamide (CAS: 10416-59-8)?

N,O-Bis(trimethylsilyl) Acetamide is primarily used in pharmaceutical and chemical research for protecting amino functionalities in complex molecules. It also finds applications in the synthesis of various organic compounds, including pharmaceutical intermediates and specialty chemicals. Its utility extends to industrial processes where controlled silylation is required.

Is N,O-Bis(trimethylsilyl) Acetamide (CAS: 10416-59-8) safe?

N,O-Bis(trimethylsilyl) Acetamide is generally considered safe when handled properly. However, it should be treated with caution as it may cause skin and eye irritation. Protective gloves, goggles, and a well-ventilated workspace are recommended. Always follow OSHA and local safety regulations for chemical handling.

How should N,O-Bis(trimethylsilyl) Acetamide (CAS: 10416-59-8) be stored?

N,O-Bis(trimethylsilyl) Acetamide should be stored in a cool, dry, and dark place, ideally at 2-8°C. It is stable under these conditions and should be kept in a sealed container to prevent moisture and air exposure. Avoid storing near incompatible materials and ensure proper ventilation to maintain safety.