1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide | CAS No. 103145-74-0
1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide
Basic Information
CAS Number
103145-74-0
Molecular Formula
C21H30N4O6
Molecular Weight
434.49 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
141-143 ºC
Synonyms & References
English
- 103145-74-0
- FT-0771473
- Z-Pro-Leu-Gly hydroxamate
- benzyl 2-[[1-[[2-(hydroxyamino)-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carboxylate
- N-carbobenzyloxy-prolyl-leucyl-glycine (N-hydroxy)amide
- DTXSID80340097
- VVGFLHRPYCTXGJ-UHFFFAOYSA-N
- Z-Pro-Leu-Gly hydroxamate, >=97% (TLC)
- Benzyl 2-(([1-(([2-(hydroxyamino)-2-oxoethyl]amino)carbonyl)-3-methylbutyl]amino)carbonyl)-1-pyrrolidinecarboxylate #
- Glycinamide,1-[(phenylmethoxy)carbonyl]-L-prolyl-L-leucyl-N-hydroxy-
- Z-PRO-LEU-GLY-NHOH
- N-CBZ-PRO-LEU-GLY hydroximate
- N-CBZ-PRO-LEU-GLY HYDROXAMATE
MDL Number
MFCD00083286
FAQ
What are the physical and chemical properties of 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide (CAS: 103145-74-0)?
1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide is a crystalline compound with a molecular weight of approximately 437.48 g/mol. It is poorly soluble in water but soluble in organic solvents like methanol and ethanol. The compound exhibits moderate reactivity, particularly in ester hydrolysis and amide formation. It is stable under normal laboratory conditions but should be stored in a desiccator to prevent moisture absorption.
How is 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide (CAS: 103145-74-0) typically synthesized?
1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide is typically synthesized via a multi-step process involving the coupling of benzyloxycarbonyl-proline with N-hydroxyleucine. The synthesis involves the use of a catalytic amount of a coupling reagent such as HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base like DIPEA (N,N-diisopropylethylamine). The reaction is carried out in an organic solvent like DMF (N,N-dimethylformamide) and the yield is approximately 70-80%.
What industries use 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide (CAS: 103145-74-0)?
1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide is primarily used in the pharmaceutical industry for the synthesis of complex peptides and proteins. It is also used in the polymer industry as a monomer for the production of certain biodegradable polymers. Additionally, it is employed in the development of sensors and semiconductors due to its unique chemical structure and reactivity.
What precautions should be taken when handling 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide (CAS: 103145-74-0)?
When handling 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be stored in a cool, dry place and handled in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent material and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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Supplier Information
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