How is 1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide (CAS: 103145-74-0) typically synthesized?

1-[(Benzyloxy)carbonyl]prolylleucyl-N-hydroxyglycinamide is typically synthesized via a multi-step process involving the coupling of benzyloxycarbonyl-proline with N-hydroxyleucine. The synthesis involves the use of a catalytic amount of a coupling reagent such as HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) and a base like DIPEA (N,N-diisopropylethylamine). The reaction is carried out in an organic solvent like DMF (N,N-dimethylformamide) and the yield is approximately 70-80%.