Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine

Basic Information

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CAS Number

102814-08-4

Molecular Formula

C9H13N2Na2O14P3

Molecular Weight

468.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Solid

Water Solubility

Soluble in water.

SMILES

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C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O

InChI

InChI=1S/C9H15N2O14P3.2Na/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17);;/q;2*+1/p-2/t5-,6+,8+;;/m0../s1

InChIKey

MYSPQSAAHPZTGA-CDNBRZBRSA-L

LogP

-0.59530

Complexity

808

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H360 May damage fertility or the unborn child
Reproductive toxicity

Synonyms & References

English

2 inverted exclamation marka-Deoxyuridine 5 inverted exclamation marka-triphosphate sodium salt
2'-Deoxyuracil 5'-triphosphate
2'-deoxy-UTP
Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, (3aS-(3aalpha,4beta,6aalpha))-
DTXSID60908053
DEOXYURIDINE-5'-TRIPHOSPHATE
CS-0256326
1173-82-6
Q28529690
2'-Deoxyuridine-5'-triphosphorate
Uridine, 2'-deoxy-, 5'-triphosphate (7CI)
N(4)-Methoxydeoxycytidine triphosphate
AHCYMLUZIRLXAA-SHYZEUOFSA-N
2'-Deoxyuridine-5'-triphosphate trisodium salt
2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-beta-D-erythro-pentofuranosyl]-
Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-
DB02333
Uridine, 2'-deoxy-, 5'-triphosphate
Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy- (9CI)
CHEBI:17625
NS00015089
Deoxyuridine triphosphate
((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
2-Deoxyuridine-5-triphosphoric acid= dutp
BDBM50205416
1-[2-Deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-4-hydroxypyrimidin-2(1H)-one
[[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
DUT
2/'-Deoxyuridine-5/'-triphosphoric acid = dUTP
Uridine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate)
2'-Deoxyuridine 5'-triphosphate

MDL Number

MFCD00084701

FAQ

What are the physical and chemical properties of Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine (CAS: 102814-08-4)?

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is a crystalline compound with a molecular weight of approximately 717.28 g/mol. It has low solubility in water and organic solvents. The compound is reactive towards nucleophilic attacks and exhibits phosphorus-oxygen bond cleavage under certain conditions. It is stable in dry form but requires careful storage under inert conditions to prevent hydrolysis.

How is Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine (CAS: 102814-08-4) typically synthesized?

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is synthesized through a multistep process involving the protection of the nucleoside, installation of the phosphorus-containing group, and subsequent deprotection. Commonly used catalysts include organotin compounds, and the synthesis typically yields 60-70% purity with high selectivity towards the desired product.

What industries use Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine (CAS: 102814-08-4)?

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is primarily used in pharmaceutical research for its nucleoside analog properties, particularly in antiviral drug development. It is also of interest in academic research for its potential applications in RNA interference and other nucleic acid-based therapies.

What precautions should be taken when handling Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine (CAS: 102814-08-4)?

When handling Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine, it is important to wear appropriate personal protective equipment (PPE), including gloves and a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using absorbent materials, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage guidelines.