Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine(CAS: 102814-08-4)

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is a crystalline compound with a molecular weight of approximately 717.28 g/mol. It has low solubility in water and organic solvents. The compound is reactive towards nucleophilic attacks and exhibits phosphorus-oxygen bond cleavage under certain conditions. It is stable in dry form but requires careful storage under inert conditions to prevent hydrolysis.

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is synthesized through a multistep process involving the protection of the nucleoside, installation of the phosphorus-containing group, and subsequent deprotection. Commonly used catalysts include organotin compounds, and the synthesis typically yields 60-70% purity with high selectivity towards the desired product.

Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine is primarily used in pharmaceutical research for its nucleoside analog properties, particularly in antiviral drug development. It is also of interest in academic research for its potential applications in RNA interference and other nucleic acid-based therapies.

When handling Disodium 2'-deoxy-5'-O-[hydroxy({[(hydroxyphosphinato)oxy]phosphinato}oxy)phosphoryl]uridine, it is important to wear appropriate personal protective equipment (PPE), including gloves and a fume hood to minimize inhalation risks. Spills should be immediately cleaned up using absorbent materials, and the area should be well-ventilated. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage guidelines.