3-Chloro-5-methoxyaniline

Basic Information

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CAS Number

10272-06-7

Molecular Formula

C7H8ClNO

Molecular Weight

157.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

280.3°Cat760mmHg

Density

1.234

Flash Point

123.3°C

Refractive Index

1.572

SMILES

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COC1=CC(=CC(=C1)N)Cl

InChI

InChI=1S/C7H8ClNO/c1-10-7-3-5(8)2-6(9)4-7/h2-4H,9H2,1H3

InChIKey

XLAVBRTYEPFKSD-UHFFFAOYSA-N

LogP

1.9308

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

110

Synonyms & References

English

GS-3664
S9BM7EE243
MFCD11035922
SB75779
3-chloro-5-methoxyphenylamine
Benzenamine, 3-chloro-5-methoxy-
SCHEMBL291988
3-Chloro-5-methoxyaniline
AM83041
FT-0704919
AN-584/43422888
A896720
AKOS006229144
3-Chloro-5-aminoanisole
CL8422
3-chloro-5-methoxy-benzenamine
10272-06-7
XLAVBRTYEPFKSD-UHFFFAOYSA-N
EN300-412474
3-chloro-5-methoxybenzenamine
NS00023173
CS-0061958
EINECS 233-614-4
J-512277
DTXSID60145466
SY108187
3-Chloro-5-methoxyphenylamine
Benzenamine,3-chloro-5-methoxy-
Einecs 233-614-4
3-chloro-5-Methoxy-benzenaMine
3-amino-5-chloroanisole

MDL Number

MFCD11035922

FAQ

What are the physical and chemical properties of 3-Chloro-5-methoxyaniline (CAS: 10272-06-7)?

3-Chloro-5-methoxyaniline is a yellow crystalline solid with a molecular weight of 191.59 g/mol. It has a melting point of 132-134°C and a boiling point of 286°C. The compound is slightly soluble in water but miscible with organic solvents like ethanol and acetone. It is known to be moderately reactive, particularly under basic conditions, and can undergo substitution reactions.

How is 3-Chloro-5-methoxyaniline (CAS: 10272-06-7) typically synthesized?

3-Chloro-5-methoxyaniline is typically synthesized via the reaction of 5-methoxyaniline with thionyl chloride. This process occurs in the presence of a catalyst, such as aluminum chloride, at room temperature. The yield is typically around 70-80%, and the product can be obtained in high purity using recrystallization.

What industries use 3-Chloro-5-methoxyaniline (CAS: 10272-06-7)?

3-Chloro-5-methoxyaniline is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also utilized in the production of dyes and pigments, and as a precursor in the development of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 3-Chloro-5-methoxyaniline (CAS: 10272-06-7)?

When handling 3-Chloro-5-methoxyaniline, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the safety data sheet (SDS).