3-Chloro-5-methoxyaniline(CAS: 10272-06-7)

3-Chloro-5-methoxyaniline is a yellow crystalline solid with a molecular weight of 191.59 g/mol. It has a melting point of 132-134°C and a boiling point of 286°C. The compound is slightly soluble in water but miscible with organic solvents like ethanol and acetone. It is known to be moderately reactive, particularly under basic conditions, and can undergo substitution reactions.

3-Chloro-5-methoxyaniline is typically synthesized via the reaction of 5-methoxyaniline with thionyl chloride. This process occurs in the presence of a catalyst, such as aluminum chloride, at room temperature. The yield is typically around 70-80%, and the product can be obtained in high purity using recrystallization.

3-Chloro-5-methoxyaniline is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It is also utilized in the production of dyes and pigments, and as a precursor in the development of sensors and semiconductors due to its unique chemical properties.

When handling 3-Chloro-5-methoxyaniline, appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. For detailed safety information, refer to the safety data sheet (SDS).