4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine

Basic Information

View in Editor

CAS Number

10244-24-3

Molecular Formula

C12H17ClN4O2

Molecular Weight

284.75 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

139-142 ºC

Boiling Point

508.7±60.0°C at 760 mmHg

SMILES

View in Editor

Clc1cc(nc(n1)N1CCOCC1)N1CCOCC1

InChI

InChI=1S/C12H17ClN4O2/c13-10-9-11(16-1-5-18-6-2-16)15-12(14-10)17-3-7-19-8-4-17/h9H,1-8H2

InChIKey

KIWUTYCMQNZUPX-UHFFFAOYSA-N

LogP

0.8031999999999999

Topological Polar Surface Area

50.72 Å²

Hydrogen Bond Donor/Acceptor

0 / 6

Complexity

285

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

4,4'-(6-Chloropyrimidine-2,4-diyl)dimorpholine
2-Pyrimidinamine, N-cyclohexyl-4-[3-phenyl-5-(1-piperidinylmethyl)-4-isoxazolyl]-
4-(4-chloro-6-morpholin-4-ylpyrimidin-2-yl)morpholine
6-Chloro-2,4-bis(4-morpholinyl)pyrimidine
4-[6-Chloro-2-(morpholin-4-yl)pyrimidin-4-yl]morpholine
Morpholine, 4,4'-(6-chloro-2,4-pyrimidinediyl)bis-
2,4-dimorpholino-6-chloropyrimidine
4-[4-chloro-6-(morpholin-4-yl)pyrimidin-2-yl]morpholine
6-Chloro-2,4-di(4-morpholinyl)pyrimidine
C12H17ClN4O2
ChemDiv1_005701
Oprea1_324570
HMS603D03
AMMD00017
KIWUTYCMQNZUPX-UHFFFAOYSA-N
BCP1

MDL Number

MFCD01873150

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3)?

4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3) is a white or off-white crystalline solid. It has a molecular weight of approximately 245.01 g/mol. The compound is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. It is known for its reactivity in nucleophilic substitution reactions due to the presence of the pyrimidine ring and morpholine groups.

How is 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3) typically synthesized?

4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine is typically synthesized through a multistep process involving the condensation of 4,4'-dichloropyrimidine with morpholine. The reaction is catalyzed by a Lewis acid such as aluminum chloride. The yield is generally high, and the product is purified by recrystallization from appropriate solvents.

What industries use 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3)?

4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3) is mainly used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the polymer industry for the preparation of advanced polymers with specific properties. Additionally, it finds applications in the production of sensors and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3)?

When handling 4,4'-(6-Chloro-2,4-pyrimidinediyl)dimorpholine (CAS: 10244-24-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using an appropriate absorbent material. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and emergency procedures.