2-Phenyl-4(1H)-quinazolinone

Basic Information

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CAS Number

1022-45-3

Molecular Formula

C14H10N2O

Molecular Weight

222.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

398.2°C at 760 mmHg

Flash Point

194.6°C

Refractive Index

1.663

SMILES

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C1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=O)N2

InChI

InChI=1S/C14H10N2O/c17-14-11-8-4-5-9-12(11)15-13(16-14)10-6-2-1-3-7-10/h1-9H,(H,15,16,17)

InChIKey

VDULOAUXSMYUMG-UHFFFAOYSA-N

LogP

2.5901000000000005

Topological Polar Surface Area

45.75 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

331

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

FT-0741948
BCP27506
2-Phenyl-3H-quinazolin-4-one
C14H10N2O
CCG-247406
SMR000567884
F0342-0101
MFCD00451430
SCHEMBL258433
2-phenyl-4-hydroxyquinazoline
BRD-K10785533-001-03-9
2-Phenyl-4-quinazolinone
CS-0156366
4(3H)-Quinazolinone, 2-phenyl-
2-phenyl-4-quinazolinol
2-phenylquinazolin-4-ol
DTXSID60299539
4(3H)-Quinazolinone,2-phenyl-
HMS1537P09
NSC400966
NSC131274
2-phenyl-1H-quinazolin-4-one
F15121
TimTec1_001395
2-Phenyl-4(3H)-quinazolinone
NSC-131274
F40
HMS2851L13
2-Phenyl-4-quinazolone
2-Phenyl-quinazolin-4-ol
BAA02245

MDL Number

MFCD00092169

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3)?

2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3) is a crystalline compound with a molecular weight of approximately 207.22 g/mol. It is soluble in common organic solvents like ethyl acetate and acetonitrile but has low solubility in water. This compound is relatively stable but can undergo thermal degradation. It reacts with various reagents such as acids and bases to form different products.

How is 2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3) typically synthesized?

2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3) can be synthesized by the condensation of 2-aminophenylacetic acid and benzaldehyde in the presence of a catalyst like p-toluenesulfonic acid. This method provides good yields and high selectivity. The product can also be obtained through the reduction of 2-phenyl-4(1H)-quinazolinone-3,4-dione.

What industries use 2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3)?

2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3) is used in the pharmaceutical industry for the development of potential antitumor agents. It also finds applications in the polymer industry for developing novel materials with specific properties. Additionally, it is utilized in the field of sensors and semiconductors due to its unique electronic and optical characteristics.

What precautions should be taken when handling 2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3)?

When handling 2-Phenyl-4(1H)-quinazolinone (CAS: 1022-45-3), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents. Always consult a safety data sheet (SDS) for detailed safety information and emergency procedures.