1-Methoxy-4-piperidinone

Basic Information

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CAS Number

102170-24-1

Molecular Formula

C6H11NO2

Molecular Weight

129.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

192 ºC

Flash Point

70 ºC

SMILES

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CON1CCC(=O)CC1

InChI

InChI=1S/C6H11NO2/c1-9-7-4-2-6(8)3-5-7/h2-5H2,1H3

InChIKey

GWMISASZFLPFMP-UHFFFAOYSA-N

LogP

0.2127000000000001

Topological Polar Surface Area

29.54 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

104

Synonyms & References

English

CEA17024
CS-0089291
4-Piperidinone, 1-methoxy-
AKOS005258977
1-methoxy-piperidin-4-one
102170-24-1
AS-58100
FT-0751178
1-METHOXYPIPERIDIN-4-ONE
SCHEMBL37337
DTXSID40601414
SB42361
MFCD16619223
N-Methoxypiperidin-4-one
N-methoxy-4-piperidone
4-Piperidinone,1-methoxy-
EN300-247529
GWMISASZFLPFMP-UHFFFAOYSA-N
1-Methoxypiperidin-4-one
1-methoxy-4-Piperidinone
1-Methoxy-piperidon-(4)
ACN-S002745
I14-31983
KB-40329
N-methoxypiperidinone
N-methoxypiperidone
SureCN37337
170M241

MDL Number

MFCD16619223

FAQ

What are the physical and chemical properties of 1-Methoxy-4-piperidinone (CAS: 102170-24-1)?

1-Methoxy-4-piperidinone is a colorless to light yellow liquid with a molecular weight of approximately 160.23 g/mol. It has a pKa of around 12.4 and a solubility of up to 15 g/L in water. It is slightly soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly towards nucleophiles and its ability to form cyclic structures under certain conditions.

How is 1-Methoxy-4-piperidinone (CAS: 102170-24-1) typically synthesized?

1-Methoxy-4-piperidinone can be synthesized by the reaction of 4-piperidone with methyl iodide in the presence of a base, such as sodium hydride. This method provides a good yield and good selectivity. Another approach involves the hydroxylation of 4-methylpiperidine followed by dehydration, often using an acid catalyst.

What industries use 1-Methoxy-4-piperidinone (CAS: 102170-24-1)?

1-Methoxy-4-piperidinone is primarily used in the pharmaceutical industry for the synthesis of drugs. It also finds application in the production of polymers, specifically as a plasticizer and in the formulation of coatings and adhesives. Additionally, it is used in the development of sensors and as a reagent in organic synthesis.

What precautions should be taken when handling 1-Methoxy-4-piperidinone (CAS: 102170-24-1)?

When handling 1-Methoxy-4-piperidinone, it is important to wear gloves, protective goggles, and a lab coat to prevent skin contact and eye exposure. It should be stored in a cool, well-ventilated area away from heat and direct sunlight. Fume hoods should be used during handling to minimize inhalation risk. In case of a spill, it should be promptly cleaned up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific guidance and emergency procedures.