1-Methoxy-4-piperidinone(CAS: 102170-24-1)

1-Methoxy-4-piperidinone is a colorless to light yellow liquid with a molecular weight of approximately 160.23 g/mol. It has a pKa of around 12.4 and a solubility of up to 15 g/L in water. It is slightly soluble in organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly towards nucleophiles and its ability to form cyclic structures under certain conditions.

1-Methoxy-4-piperidinone can be synthesized by the reaction of 4-piperidone with methyl iodide in the presence of a base, such as sodium hydride. This method provides a good yield and good selectivity. Another approach involves the hydroxylation of 4-methylpiperidine followed by dehydration, often using an acid catalyst.

1-Methoxy-4-piperidinone is primarily used in the pharmaceutical industry for the synthesis of drugs. It also finds application in the production of polymers, specifically as a plasticizer and in the formulation of coatings and adhesives. Additionally, it is used in the development of sensors and as a reagent in organic synthesis.

When handling 1-Methoxy-4-piperidinone, it is important to wear gloves, protective goggles, and a lab coat to prevent skin contact and eye exposure. It should be stored in a cool, well-ventilated area away from heat and direct sunlight. Fume hoods should be used during handling to minimize inhalation risk. In case of a spill, it should be promptly cleaned up with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific guidance and emergency procedures.