2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile | CAS No. 1021298-68-9
2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile
Basic Information
CAS Number
1021298-68-9
Molecular Formula
C16H10FN3O
Molecular Weight
279.27 g/mol
AD
Chemical Classification
Basic Physical Properties
Safety Information
View Safety InformationGHS Hazard Pictograms
H302Hazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
Synonyms & References
English
- 5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzonitrile
- 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzonitrile
- 2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzonitrile
- 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile
- 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile
- LCPWJQRZOHAMOZ-UHFFFAOYSA-N
- SY047477
- AK203043
MDL Number
MFCD28133450
FAQ
What are the physical and chemical properties of 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile (CAS: 1021298-68-9)?
2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is a crystalline solid with a molecular weight of 324.18 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, showing some electrophilic substitution and nucleophilic addition reactivity. It has a melting point of approximately 210-212°C.
How is 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile (CAS: 1021298-68-9) typically synthesized?
2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is synthesized by the condensation of 2-fluorobenzonitrile with 4-aminophthalic anhydride. The reaction is catalyzed by a Lewis acid such as aluminum chloride, and it typically yields a high purity product with good selectivity. The reaction proceeds efficiently in dichloromethane at room temperature, with a yield of around 85-90%.
What industries use 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile (CAS: 1021298-68-9)?
2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is primarily used in the pharmaceutical industry as an intermediate for synthesizing active pharmaceutical ingredients. It also finds applications in the production of polymers, where it can be used as a monomer or additive. Additionally, it has potential uses in sensor technology and semiconductor manufacturing due to its unique chemical properties.
What precautions should be taken when handling 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile (CAS: 1021298-68-9)?
When handling 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry environment away from heat sources. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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