2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile(CAS: 1021298-68-9)

2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is a crystalline solid with a molecular weight of 324.18 g/mol. It is sparingly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, showing some electrophilic substitution and nucleophilic addition reactivity. It has a melting point of approximately 210-212°C.

2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is synthesized by the condensation of 2-fluorobenzonitrile with 4-aminophthalic anhydride. The reaction is catalyzed by a Lewis acid such as aluminum chloride, and it typically yields a high purity product with good selectivity. The reaction proceeds efficiently in dichloromethane at room temperature, with a yield of around 85-90%.

2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile is primarily used in the pharmaceutical industry as an intermediate for synthesizing active pharmaceutical ingredients. It also finds applications in the production of polymers, where it can be used as a monomer or additive. Additionally, it has potential uses in sensor technology and semiconductor manufacturing due to its unique chemical properties.

When handling 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzonitrile, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry environment away from heat sources. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.