1-(2,5-Dimethylphenyl)piperazine

Basic Information

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CAS Number

1013-25-8

Molecular Formula

C12H18N2

Molecular Weight

190.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

44.0 to 48.0 deg-C

Boiling Point

154°C/10mmHg

Flash Point

154°C/10mm

Refractive Index

1.5586 (estimate)

SMILES

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CC1=CC(=C(C=C1)C)N2CCNCC2

InChI

InChI=1S/C12H18N2/c1-10-3-4-11(2)12(9-10)14-7-5-13-6-8-14/h3-4,9,13H,5-8H2,1-2H3

InChIKey

YRIFWVMRUFKWLM-UHFFFAOYSA-N

LogP

1.7130399999999997

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

175

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Synonyms & References

English

AKOS000268460
Z594273860
N-(2,5-Dimethylphenyl)piperazine
2,5-dimethylphenylpiperazine
CCG-15392
1-(2,5-Dimethylphenyl)piperazine, AldrichCPR
LF-0550
DTXSID20143827
NS00023050
1013-25-8
SCHEMBL255418
1-(2,5-Dimethylphenyl)piperazine
FT-0629091
Piperazine, 1-(2,5-dimethylphenyl)-
1-(2,5-Xylyl)piperazine
EINECS 213-795-6
F1939-1103
MFCD00038378
4-(2,5-dimethyl-phenyl)piperazine
EN300-110636
1-(2,5-dimethylphenyl)-piperazine
EU-0001028
1-(2,5-Dimethyl-phenyl)-piperazine
D5659
BAA01325
(2,5-dimethylphenyl)piperazine
1-(2,5-dimethyl-phenyl)-piperazine
1-(2,5-xylyl)piperazine
4-(2,5-dimethylphenyl)piperazin
4-(2,5-dimethylphenyl)piperazine
AKOS BB-5740

MDL Number

MFCD00038378

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8)?

1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8) is a white crystalline solid with a molecular weight of approximately 215.32 g/mol. It has good solubility in organic solvents like dimethylformamide and toluene. Chemically, it is relatively stable but can undergo ring-opening reactions under basic conditions.

How is 1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8) typically synthesized?

1-(2,5-Dimethylphenyl)piperazine can be synthesized via a condensation reaction between 2,5-dimethylphenol and piperazine, facilitated by a strong base like sodium hydride. The reaction gives a high yield of 85-90%, with good selectivity towards the desired product.

What industries use 1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8)?

1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also has applications in the polymer industry for modifying polymer properties and in the electronics industry for use in semiconductors.

What precautions should be taken when handling 1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8)?

When handling 1-(2,5-Dimethylphenyl)piperazine (CAS: 1013-25-8), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from heat and direct sunlight. In case of a spill, use appropriate clean-up materials and consult the Safety Data Sheet (SDS) for detailed instructions.