5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | CAS No. 1009820-21-6
5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid
Basic Information
CAS Number
1009820-21-6
Molecular Formula
C19H12ClN3O2
Molecular Weight
349.78 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
568.4°C at 760 mmHg
Safety Information
View Safety InformationHazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H332
Harmful if inhaled
Acute toxicity, inhalation
Acute toxicity, inhalation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- 5-((3-Chlorophenyl)amino)benzo[c][2,6]naphthyridine-8-carboxylic acid
- 5-((3-Chlorophenyl)amino)benzo-[c][2,6]naphthyridine-8-carboxylic acid
- 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid
- 5-[(3-chlorophenyl)amino]-Benzo[c]-2,6-naphthyridine-8-carboxylic acid
- CX-4945
- CX-4945 (CX 4945, CX4945, Silmitasertib)
- CX-4945 (Silmitasertib)
- CX-4945 Silmitasertib
- CX-4945
- Silmitasertib
- 5-(3-chloroanilino)benzo[c][2,6]naphthyridine-8-carboxylic acid
- CX 4945
- 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid
- CX-4945, CX4945
- Silmitasertib(CX-4945)
- 5-[(3-Chlorophenyl)amino]benzo[c]-2,6-naphthyridine-8-carboxylic acid CX-4945 (Silmitasertib)
- CX4945
- C6RWP0N0L2
- 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-Carboxylic Acid
- 5-((3-Chl
MDL Number
MFCD13184796
Customs Code
2933990090
FAQ
What are the physical and chemical properties of 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (CAS: 1009820-21-6)?
5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid is a crystalline solid with a molecular weight of approximately 396.02 g/mol. It has low solubility in water but is soluble in common organic solvents like DMSO and DMF. The compound shows moderate basicity and has a pKa of around 8.5. It is stable under normal conditions but can undergo hydrolysis under basic conditions. Reactivity is moderate and it is generally inert under standard laboratory conditions.
How is 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (CAS: 1009820-21-6) typically synthesized?
The compound can be synthesized via a multi-step process involving amide formation and condensation reactions. A typical method involves the coupling of 3-chloroaniline with 8-carboxybenzo[c][2,6]naphthyridine using a suitable coupling agent like HATU in the presence of a base such as DIPEA. The yield is around 75-80%, and the product can be purified by recrystallization from appropriate solvents.
What industries use 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (CAS: 1009820-21-6)?
This compound is primarily used in the pharmaceutical industry for its potential medicinal properties. It can serve as a lead compound for developing new drugs targeting various diseases. Additionally, it may find applications in the chemical industry as a reagent or intermediate in the synthesis of other compounds.
What precautions should be taken when handling 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid (CAS: 1009820-21-6)?
When handling 5-[(3-Chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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