delta-2-Ceftazidime

Basic Information

View in Editor

CAS Number

1000980-60-8

Molecular Formula

C22H22N6O7S2

Molecular Weight

546.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

View in Editor

CC(C)(C(=O)O)ON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(C(=CS3)C[N+]4=CC=CC=C4)C(=O)[O-]

InChI

InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,9-10,14-15,18H,8H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,15?,18-/m1/s1

InChIKey

LRKHKETXQNDOKF-YTAHGSIGSA-N

Complexity

1010

Synonyms & References

English

?2-Ceftazidime
2-Ceftazidime
(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-(Z)-(2,2-dimethylacetoxyimino)acetamido]-3-[(pyridinium)methyl]-2-cephem-4-carboxylate
∆2-Ceftazidime
(2RS,6R,7R)-7-[[(2Z)-2-(2-AMINOTHIAZOL-4-YL)-2-[(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL]AMINO]-8-OXO-3-[(1-PYRIDINIO)METHYL]-5-THIA-1-AZABICYCLO[4.2.0]OCT-3-ENE-2-CARBOXYLATE (Δ-2-CEFTAZIDIME)
CEFTAZIDIME IMPURITY A
Ceftazidime EP Impurity A
1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-en-3-yl]methyl]pyridinium inner salt
(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
.DELTA.-2-CEFTAZIDIME, (+/-)-
Delta 2-Ceftazidime
CEFTAZIDIME PENTAHYDRATE IMPURITY A [EP IMPURITY]
CS-0166370
A898827
UNII-97OBN5O836
1000980-60-8
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate
217796-42-4
CEFTAZIDIME IMPURITY A [EP IMPURITY]
97OBN5O836
.DELTA.-2-CEFTAZIDIME
delta-2-Ceftazidime
PYRIDINIUM, 1-(((6R,7R)-7-(((2Z)-2-(2-AMINO-4-THIAZOLYL)-2-((1-CARBOXY-1-METHYLETHOXY)IMINO)ACETYL)AMINO)-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO(4.2.0)OCT-3-EN-3-YL)METHYL)-, INNER SALT
(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate (Ceftazidime Impurity
AKOS025394532
CEFTAZIDIME DELTA-3-ISOMER [USP-RS]
(2RS,6R,7R)-7-(((2Z)-2-(2-AMINOTHIAZOL-4-YL)-2-((1-CARBOXY-1-METHYLETHOXY)IMINO)ACETYL)AMINO)-8-OXO-3-((PYRIDIN-1-IUM-1-YL)METHYL)-5-THIA-1-AZABICYCLO(4.2.0)OCT-3-ENE-2-CARBOXYLATE
Ceftazidime Impurity A

MDL Number

MFCD21363482

FAQ

What are the physical and chemical properties of delta-2-Ceftazidime (CAS: 1000980-60-8)?

Delta-2-Ceftazidime (CAS: 1000980-60-8) is a crystalline antibiotic with a molecular weight of approximately 622.75 g/mol. It is slightly soluble in water and has good solubility in organic solvents. The compound exhibits good reactivity towards hydrolysis under basic conditions. Its chemical stability is maintained under neutral and slightly acidic pH conditions.

How is delta-2-Ceftazidime (CAS: 1000980-60-8) typically synthesized?

Delta-2-Ceftazidime is typically synthesized via a multi-step process involving the acetylation of a cephalosporin nucleus, followed by ring opening and modification reactions. Commonly used catalysts include acid or base catalysts, and the reaction conditions are optimized for high selectivity and yield. The synthesis process requires precise control over reaction temperature and time.

What industries use delta-2-Ceftazidime (CAS: 1000980-60-8)?

Delta-2-Ceftazidime (CAS: 1000980-60-8) is primarily used in the pharmaceutical industry for the treatment of bacterial infections. It is also employed in the development of cephalosporin-based antimicrobial agents. Due to its broad-spectrum activity, it is often utilized in hospitals and clinics for various medical applications.

What precautions should be taken when handling delta-2-Ceftazidime (CAS: 1000980-60-8)?

When handling delta-2-Ceftazidime (CAS: 1000980-60-8), it is essential to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risk. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly decontaminated. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.