Compound Q&A

How is 1-(4-Chlorophenyl)cyclopropanecarbonyl chloride (CAS: 78682-33-4) typically synthesized?

Answer

1-(4-Chlorophenyl)cyclopropanecarbonyl chloride
1-(4-Chlorophenyl)cyclopropanecarbonyl chloride is typically synthesized via the reaction of 4-chlorophenylacetic acid with thionyl chloride. This method involves the gradual addition of thionyl chloride to a solution of 4-chlorophenylacetic acid in an inert solvent like toluene, followed by distillation to remove excess thionyl chloride. The process yields a high yield of the title compound, which is purified by recrystallization.

About

CAS No 78682-33-4
English Name 1-(4-Chlorophenyl)cyclopropanecarbonyl chloride
Molecular Formula C10H8Cl2O
Molecular Weight 215.08 g/mol
SMILES C1CC1(C2=CC=C(C=C2)Cl)C(=O)Cl
InChIKey SJONAMDHFQGIQE-UHFFFAOYSA-N
Last Updated: 2026-03-31 17:51

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