1-(4-Chlorophenyl)cyclopropanecarbonyl chloride(CAS: 78682-33-4)

1-(4-Chlorophenyl)cyclopropanecarbonyl chloride (CAS: 78682-33-4) is a white crystalline solid with a molecular weight of approximately 229.63 g/mol. It has a low solubility in water but is soluble in organic solvents such as ethanol and chloroform. The compound is highly reactive, particularly with amines and nucleophiles, and is known for its potent electrophilic character.

1-(4-Chlorophenyl)cyclopropanecarbonyl chloride is typically synthesized via the reaction of 4-chlorophenylacetic acid with thionyl chloride. This method involves the gradual addition of thionyl chloride to a solution of 4-chlorophenylacetic acid in an inert solvent like toluene, followed by distillation to remove excess thionyl chloride. The process yields a high yield of the title compound, which is purified by recrystallization.

1-(4-Chlorophenyl)cyclopropanecarbonyl chloride (CAS: 78682-33-4) is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also employed in the production of certain polymers and as an intermediate in the development of new materials. Its use in sensors and semiconductors, although less common, is also reported.

When handling 1-(4-Chlorophenyl)cyclopropanecarbonyl chloride (CAS: 78682-33-4), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be handled with caution, using a mild base to neutralize the acid chloride, followed by thorough cleaning. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.