Compound Q&A
How is 1-(4-Nitrophenyl)-4-piperidinecarboxylic acid (CAS: 223786-53-6) typically synthesized?
Answer
1-(4-Nitrophenyl)-4-piperidinecarboxylic acid is typically synthesized via the condensation of 4-nitrophenyl chloroformate with piperidine. The reaction is carried out under anhydrous conditions, with triethylamine as a base and dichloromethane as the solvent. This method provides good selectivity and yield, making it a common approach in the chemical industry.
About
CAS No
223786-53-6
English Name
1-(4-Nitrophenyl)-4-piperidinecarboxylic acid
Molecular Formula
C12H14N2O4
Molecular Weight
250.25 g/mol
SMILES
OC(=O)C1CCN(CC1)c1ccc(cc1)[N+](=O)[O-]
InChIKey
ZIRBMAVPCZUDTF-UHFFFAOYSA-N
Last Updated: 2026-03-23 08:16
