Compound Q&A
How is (S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid (CAS: 3978-11-8) typically synthesized?
Answer
(S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid (CAS: 3978-11-8) can be synthesized through the condensation of 2-formamidophenylacetic acid with glycine under mild conditions. Common methods include using a dehydrating agent like dicyclohexylcarbodiimide (DCC) in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) as a base. The yield is typically around 70-80% with high selectivity for the (S) enantiomer.
About
CAS No
3978-11-8
English Name
(S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid
Molecular Formula
C11H12N2O4
Molecular Weight
236.23 g/mol
SMILES
C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)NC=O
InChIKey
BYHJHXPTQMMKCA-QMMMGPOBSA-N
Last Updated: 2026-01-01 15:34
