Compound Q&A
How is 2,5-Dichloro-N-[2-(isopropylsulfanyl)phenyl]-4-pyrimidinamine (CAS: 1632485-14-3) typically synthesized?
Answer
![2,5-Dichloro-N-[2-(isopropylsulfanyl)phenyl]-4-pyrimidinamine](https://static.chemtradehub.com/structs/163/1632485-14-3-0fdc.webp "2,5-Dichloro-N-[2-(isopropylsulfanyl)phenyl]-4-pyrimidinamine")
2,5-Dichloro-N-[2-(isopropylsulfanyl)phenyl]-4-pyrimidinamine is typically synthesized via a multistep process involving the reaction of 2-chloro-4-pyrimidinamine with 2-(isopropylthio)benzaldehyde. The synthesis usually involves a palladium-catalyzed cross-coupling reaction, followed by a nucleophilic substitution step. The yield is around 70-80%, and the purity is above 95%.
About
CAS No
1632485-14-3
English Name
2,5-Dichloro-N-[2-(isopropylsulfanyl)phenyl]-4-pyrimidinamine
Molecular Formula
C13H13Cl2N3S
Molecular Weight
314.24 g/mol
SMILES
CC(C)Sc1ccccc1Nc2c(cnc(n2)Cl)Cl
InChIKey
XBNWAVDIFJHCOK-UHFFFAOYSA-N
Last Updated: 2026-01-01 10:50
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