Compound Q&A
How is [4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid (CAS: 313545-40-3) typically synthesized?
Answer
![[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid](https://static.chemtradehub.com/structs/313/313545-40-3-0c10.webp "[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid")
[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid is typically synthesized via a coupling reaction between 4-isopropoxy-2-(trifluoromethyl)phenol and boronic acid derivatives using a catalyst such as palladium(II) acetate in the presence of a phase-transfer catalyst and a base like triphenylphosphine. This method yields high selectivity and good to excellent yield depending on the reaction conditions.
About
CAS No
313545-40-3
English Name
[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid
Molecular Formula
C10H12BF3O3
Molecular Weight
248.01 g/mol
SMILES
B(C1=C(C=C(C=C1)OC(C)C)C(F)(F)F)(O)O
InChIKey
MQWMPOPSYRZCAI-UHFFFAOYSA-N
Last Updated: 2026-01-01 01:49
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