[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid(CAS: 313545-40-3)

[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid is a white crystalline solid with a molecular weight of approximately 327.12 g/mol. It has a low solubility in water but is soluble in organic solvents like dichloromethane and acetonitrile. The compound is known for its moderate reactivity in boronate ester formation and is often used as a building block in organic synthesis. Its physical properties include a melting point of 118-119°C.

[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid is typically synthesized via a coupling reaction between 4-isopropoxy-2-(trifluoromethyl)phenol and boronic acid derivatives using a catalyst such as palladium(II) acetate in the presence of a phase-transfer catalyst and a base like triphenylphosphine. This method yields high selectivity and good to excellent yield depending on the reaction conditions.

[4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid is primarily used in the pharmaceutical industry for the synthesis of complex organic molecules, particularly in the field of medicinal chemistry. It is also utilized in the polymer industry for the development of new materials with specific properties. Additionally, it finds applications in the sensor technology and semiconductor manufacturing sectors due to its unique chemical functionality.

When handling [4-Isopropoxy-2-(trifluoromethyl)phenyl]boronic acid, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to air. Spills should be cleaned up promptly using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed information and emergency procedures. The compound should be stored in a cool, dry place away from direct sunlight and incompatible materials.