Compound Q&A
How is (2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide (CAS: 2226521-65-7) typically synthesized?
Answer
![(2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide](https://static.chemtradehub.com/structs/222/2226521-65-7-d58e.webp "(2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide")
This compound is synthesized via a multistep process involving the condensation of a cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl derivative with a 2-furyl cyanoacrylamide. The reaction is typically catalyzed by a palladium complex and proceeds in an organic solvent like DMF. The yield is moderate to good, and the selectivity is high, with a single diastereomer being formed.
About
CAS No
2226521-65-7
English Name
(2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide
Molecular Formula
C24H24N6O2
Molecular Weight
428.49 g/mol
SMILES
N#C/C(=C\c1ccc(o1)c1nc2c(n1C1CCCCC1)c1cc[nH]c1nc2)/C(=O)N(C)C
InChIKey
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Last Updated: 2025-12-25 04:58
![(2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide — Huifei Mokai Medicinal Technology Co., Ltd.](https://static.chemtradehub.com/suppliers/67cdef8657537e5c8069afb0/67cdef8657537e5c8069afb0-logo.webp){kind=logo}
![(2E)-2-Cyano-3-[5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furyl]-N,N-dimethylacrylamide — ShangHaiChuangSai Technology Co Ltd](https://static.chemtradehub.com/suppliers/67cecce82b2de6e8e95a5e02/67cecce82b2de6e8e95a5e02-logo.webp){kind=logo}