How is 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine (CAS: 865305-30-2) typically synthesized?

5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine is typically synthesized through a multi-step process involving the protection of the methoxy group, introduction of the isopropyl group, followed by iodination and the final pyrimidine coupling. This synthesis often requires the use of reagents like N,N-dimethylformamide (DMF), sodium iodide, and a palladium catalyst. The yield is moderate, around 50-70%, and the selectivity is high.