5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine(CAS: 865305-30-2)

5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine is a crystalline compound with a molecular weight of approximately 451.26 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetone. This compound is reactive towards nucleophiles and electrophiles. It can undergo nucleophilic substitution reactions and can be used in the synthesis of other compounds.

5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine is typically synthesized through a multi-step process involving the protection of the methoxy group, introduction of the isopropyl group, followed by iodination and the final pyrimidine coupling. This synthesis often requires the use of reagents like N,N-dimethylformamide (DMF), sodium iodide, and a palladium catalyst. The yield is moderate, around 50-70%, and the selectivity is high.

5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine is primarily used in the pharmaceutical industry for the development of novel drugs. It also finds applications in the synthesis of organic semiconductors and in the development of advanced materials for sensors and polymers. Its unique structure makes it valuable in these fields.

Precautions when handling 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine include the use of personal protective equipment such as gloves, goggles, and lab coats. It should be stored in a well-ventilated area away from direct sunlight and heat. Spills should be handled with caution using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.