2-Methyl-4-(Trifluoromethyl) Thiazole-5-Carboxylic Acid(CAS: 117724-63-7)

2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid is a crystalline solid with a molecular weight of 269.97 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetonitrile. It is a weak acid with limited reactivity under normal conditions. This compound is stable under acidic and basic conditions but can be sensitive to strong oxidizing agents.

2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid is typically synthesized via the reaction of 2-methylthiazole-4-carboxylic acid with trifluoromethylsulfonyl chloride, followed by hydrolysis. This process involves the use of a phase transfer catalyst and is carried out under mild conditions to achieve good yield and selectivity.

2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid is used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the sensor technology and semiconductor industries due to its unique chemical properties.

When handling 2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be handled with caution, and proper disposal procedures should be followed. Always consult the Safety Data Sheet (SDS) for detailed information on handling and safety precautions.