Methyl 2-fluoro-3-oxopentanoate

Basic Information

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CAS Number

180287-02-9

Molecular Formula

C6H9FO3

Molecular Weight

148.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

170.1℃ at 760 mmHg

SMILES

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CCC(=O)C(C(=O)OC)F

InChI

InChI=1S/C6H9FO3/c1-3-4(8)5(7)6(9)10-2/h5H,3H2,1-2H3

InChIKey

ZHQHSDROMAJDFS-UHFFFAOYSA-N

LogP

0.4766

Topological Polar Surface Area

43.370000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

144

Synonyms & References

English

Methyl 2-fluoro-3-oxovalerate
CS-M3568
ZHQHSDROMAJDFS-UHFFFAOYSA-N
methyl 2-fluoranyl-3-oxidanylidene-pentanoate
2-Fluoro-3-oxopentanoicacidmethylester
pentanoic acid, 2-fluoro-3-oxo-, methyl ester
O11876
AKOS005064031
MFCD00792442
2-Fluoro-3-oxo-pentanoic acid methyl ester
AM62556
METHYL 2-FLUORO-3-OXOPENTANOATE
LGE835JYU6
180287-02-9
BCP08802
2-Fluoro-3-oxovaleric acid methyl ester
2-fluoro-3-oxopentanoic acid methyl ester
Methyl2-fluoro-3-oxopentanoate
5-METHYL-2-THIOPHENECARBOXYLICACIDHYDRAZIDE
FT-0643740
EN300-1457738
DTXSID80436843
M3282
A812540
SCHEMBL736773
AS-50309
Methyl 2-fluoro-3-oxopentanoate
methyl ester of 2-fluoro-3-oxopentanoic acid
methyl-2-fluoro-3-oxopentanoate
Methyl 2-Fluoro-3-Oxo-Valerate
2-FLUORO-3-KETOVALERIC ACID METHYL ESTER

MDL Number

MFCD00792442

Customs Code

2918300090

FAQ

What are the physical and chemical properties of Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9)?

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is a colorless liquid with a molecular weight of approximately 131.06 g/mol. It has a high boiling point around 210°C and is moderately soluble in water. It is reactive towards nucleophiles and can undergo hydrolysis under basic conditions. This compound is stable under normal conditions but should be stored in a cool, dry place away from moisture and strong bases.

How is Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) typically synthesized?

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is typically synthesized through a condensation reaction between a fluoro carboxylic acid and an alcohol using a coupling agent like dicyclohexylcarbodiimide (DCC). The reaction is usually conducted in an inert solvent like dichloromethane and requires the presence of a catalytic amount of 4-dimethylaminopyridine (DMAP) to enhance the reaction yield. The final product can be isolated by filtration and recrystallization.

What industries use Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9)?

Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the manufacturing of polymers and in the development of sensors and semiconductors due to its unique chemical properties. Its versatility makes it a valuable compound in multiple sectors.

What precautions should be taken when handling Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9)?

When handling Methyl 2-fluoro-3-oxopentanoate (CAS: 180287-02-9), it is important to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or in a fume hood to avoid inhalation. Spills should be handled with caution using appropriate absorbents, and the area should be cleaned thoroughly. Always consult the safety data sheet (SDS) for detailed handling and storage guidelines.