(2-Bromophenyl)methanesulfonyl chloride(CAS: 24974-74-1)

(2-Bromophenyl)methanesulfonyl chloride is a solid at room temperature with a melting point of approximately 94-97°C. Its molecular weight is about 287.04 g/mol. The compound is poorly soluble in water but soluble in organic solvents like dichloromethane and ethanol. It is highly reactive, particularly towards nucleophiles, and can undergo sulfonation and bromination reactions.

(2-Bromophenyl)methanesulfonyl chloride is usually synthesized by reacting 2-bromophenylmethane with methanesulfonyl chloride in the presence of a base like triethylamine. The reaction is typically carried out in dichloromethane under anhydrous conditions. The yield is high, and the product is isolated by acid work-up and recrystallization.

(2-Bromophenyl)methanesulfonyl chloride is used in the pharmaceutical industry for the synthesis of certain drugs, in polymer chemistry for the modification of polymers, and in sensor technology for the development of chemical sensors. Its reactivity makes it useful in various chemical transformations and derivatizations.

When handling (2-Bromophenyl)methanesulfonyl chloride, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat is necessary. The compound should be handled in a well-ventilated area or a fume hood due to its strong odor and potential reactivity. Spills should be cleaned up immediately with appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.