Fmoc-a-Me-Asp(OtBu)-OH(CAS: 1072845-47-6)

Fmoc-a-Me-Asp(OtBu)-OH (CAS: 1072845-47-6) is a solid, crystalline compound with a molecular weight of approximately 408.4 g/mol. It has limited solubility in water and is more soluble in organic solvents like methanol and dimethylformamide. This compound exhibits limited reactivity in aqueous environments but is stable under dry and anhydrous conditions. It is often used in peptide synthesis due to its high purity and reactivity.

Fmoc-a-Me-Asp(OtBu)-OH (CAS: 1072845-47-6) is synthesized through the coupling of a protected amino acid and a protected aspartic acid derivative. The synthesis involves the use of HATU as a coupling agent and DIPEA as a base. This method provides high yields and good selectivity, making it a common approach in solid-phase peptide synthesis.

Fmoc-a-Me-Asp(OtBu)-OH (CAS: 1072845-47-6) is primarily used in the pharmaceutical industry for the synthesis of peptides and proteins. It is also applied in research and development for drug discovery and in the polymer industry for the preparation of functional polymers. Additionally, it is used in the production of sensors and semiconductors.

When handling Fmoc-a-Me-Asp(OtBu)-OH (CAS: 1072845-47-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure to air. Spills should be cleaned up immediately using appropriate absorbent materials. Refer to the safety data sheet (SDS) for detailed handling and disposal instructions.