2-Chloro-4-methoxynicotinaldehyde(CAS: 905563-79-3)

2-Chloro-4-methoxynicotinaldehyde is a crystalline solid with a molecular weight of approximately 185.65 g/mol. It has a solubility of about 1.5 g/L in water and is slightly soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive toward nucleophiles and reduces under basic conditions. It is also prone to hydrolysis in aqueous solutions.

2-Chloro-4-methoxynicotinaldehyde can be synthesized via the reaction of 4-hydroxy-2-chloronicotinaldehyde with methanol in the presence of a catalytic amount of phosphoric acid. The yield is typically around 85%, and the reaction is highly selective. The product can be purified by recrystallization from water or suitable organic solvents.

2-Chloro-4-methoxynicotinaldehyde is primarily used in pharmaceuticals for the synthesis of various drug intermediates. It is also utilized in the production of certain dyes and pigments due to its chromophoric properties. Additionally, it has applications in the field of analytical chemistry as a reagent in spectroscopic studies and as a component in certain sensors.

Proper handling of 2-Chloro-4-methoxynicotinaldehyde requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of vapors. Spills should be cleaned up with caution, using absorbent materials, and the area should be flushed with water. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety guidelines and emergency procedures.